The Nathan lab is in the Department of Microbiology and Immunology at Weill Cornell Medicine in NYC. The lab studies host-pathogen interactions, focusing on macrophages and Mycobacterium tuberculosis (Mtb). Most projects in the lab today fall into one or more of the following broad topics: host pathways controlling susceptibility and resistance to Mtb; biology of Mtb in non-replicating (NR) states; and approaches to overcome the phenotypic resistance of non-replicating Mtb to most antibiotics by developing new kinds of antimicrobial molecules.
These campaigns call on disciplines ranging from immunology and microbiology to biochemistry and medicinal chemistry. Reflecting that, the lab is multi-disciplinary and highly collaborative. Much of our work with academic and industrial partners takes place via the Bill & Melinda Gates Foundation TB Drug Accelerator and the NIH-funded Tri-Institutional TB Research Unit (C. Nathan, Principal Investigator).