Full list of publications: 


Selected publications:

E. Ballinger, J. Mosior, T. Hartman, K. Burns-Huang, B. Gold, R. Morris, L. Goullieux, I. Blanc, J. Vaubourgeix, S. Lagrange, L. Fraisse, S. Sans, C. Couturier, E. Bacqué, K. Rhee, S. M. Scarry, J. Aubé, G. Yang, O. Ouerfelli, D. Schnappinger, T. R. Ioerger, C. A. Engelhart, J. A. McConnel, K. McAulay, A. Fay, C. Roubert, J. Sacchettini, C. Nathan. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science 363: eaau8959, 2019 Link

H. Yu, T. J. Lupoli, A. Kovach, X. Meng, G. Zhao, C. F. Nathan and H. Li. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. Proc. Natl. Acad. Sci. USA 115: E9560-E9569, 2018 Link

L. A. Kirkman, W. Zhan, J. Visone, A. Dziedziech, P. K. Singh, H. Fan, X. Tong, I. Bruzual, R. Hara, M. Kawasaki, T. Imaeda, R. Okamoto, K. Sato, M. Michino, E. Alvero, L. F. Guiang, L. Sanz, D. J. Mota, K. Fovindasamy, R. Wang, Y. Ling, P. K. Tumwebaze, G. Sukenick, L. Shi, J. Vendome, P. Bhanot, P. J. Rosenthal, K. Aso, M. A. Foley, R. A. Cooper, B. Kafsack, J. S. Doggett, C. F. Nathan and G. Lin. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc. Natl. Acad. Sci. USA 115: E6863-E6870, 2018 Link

C. Nathan.  Kunkel Lecture:  Fundamental immunodeficienty and its correctionJ. Exp. Med. 214:  2175-2191, 2017   PDF

K. Saito, T. Warrier, S. Somersan-Karakaya, L. Kaminski, J. Mi, X. Jiang, S. Park, K. Shigyo, B. Gold, J. Roberts, E. Weber, W. R. Jacobs, Jr., and C. Nathan.  Rifamycin action on RNA polymerase in antibiotic tolerant Mycobacterium tuberculosis results in differentially detectable populations.  Proc. Natl. Acad. Sci. USA  114:  E4832-E4840, 2017   PDF 

E. Sula Karecci, H. Fan, M. Uehara, A. Mihali, P. K. Singh, A. Kurdi, Z. Solhjou, L. Riella, I. Ghobriel, T. Laragione, S. Routray, J. P. Assaker, R. Wang, L. Shi, F. J. Barrat, C. F. Nathan, G. Lin and J. Azzi.  Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in miceProc. Natl. Acad. Sci. USA  113:  E8425-E8431, 2017   PDF

T. Lupoli, A. Fay, C. Adura, M. S. Glickman and C. Nathan.  Reconstitution of a proteostasis pathway in Mycobacterium tuberculosis highlights essential cofactor interactions with chaperone DnaKProc. Natl Acad. Sci. USA  E7947-E7956, 2016   PDF

J. Vaubourgeix, G. Lin, N. Dhar, N. Chenouard, X. Jiang, H. Botella, T. Lupoli, O. Mariani, G. Yang, O. Ouerfelli, M. Unser, D. Schnappinger, J. McKinney and C. Nathan. Asymmetric distribution of irreversibly oxidized, ClpB-associated proteins in stressed mycobacteria. Cell Host and Microbe 117: 179-190, 2015 PDF

M. Nandakumar, C. Nathan and K. Y. Rhee. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature Communications 5: 4306, 2014 PDF

R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima and C. Nathan. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52: 9375-9384, 2013 PDF

Rath, P., C. Huang, T. Wang, T. Wang, H. Li, R. Prados-Rosales, O. Elemento, A. Casadevall and C. Nathan. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 8: E4790-4797, 2013 PDF

Cunningham-Bussel, A., T. Zhang and C. F. Nathan. Nitrite produced by M. tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proc. Natl. Acad. Sci. USA 110: E4256-E4265, 2013 PDF

Lin, G, T. Chidawanyika, C. Tsu, T. Warrier, J. Vaubourgeix, C. Blackburn. K. Gigstad, M. Sintchak, L. Dick and C. Nathan. N,C-capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: Role of S3 and S1 binding pockets. J. Am. Chem. Soc. 135: 99689971, 2013 PDF

Balakrishnan, A., F. Jordan and C. Nathan. Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. J. Biol. Chem. 288: 21714-21728, 2013 PDF

B.  Gold, M. Pingle, S. J. Brickner,  N. Shah, J. Roberts, M. Rundell, W. Clay Bracken, T. Warrier, S. Somersan, A. Venugopal, C. Darby, X. Jiang, J. D. Warren, J. Fernandez, O. Ouerfelli, E. L. Nuermberger, A. Cunningham-Bussel, P. Rath, H. Deng, R. Realubit, J. F. Glickman and C. Nathan. A non-steroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc. Natl. Acad. Sci. USA 109: 16004-16011, 2012 PDF

Venugopal, A., Bryk, R., Shi, S., Rhee, K., Rath, P., Schnappinger, D., Ehrt, S. and Nathan, C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multi-enzyme complexes. Cell Host and Microbe 9: 21-31, 2011 PDF